Torsemide is the generic name of the brandname drug demadex, used to treat high blood pressure and swelling caused by heart, kidney, or liver disease the prescription medicine belongs to a. The optimum experimental parameters for the reaction have been studied. Glucose monitoring is important when initializing or adjusting mecasermin therapies, when adjusting concomitant antidiabetic therapy, and in the event of hypoglycemic symptoms. Pdf longterm stability of a compounded suspension of. These highlights do not include all the information needed to use advate safely and effectively. Use of torsemide has been found to be effective for the treatment of edema associated with chronic renal failure. Aug 22, 2019 apidra solostar unitsml solution for injection in a prefilled pen. Aug 31, 2018 bumetanide, apidra package insert, and torsemide may cause hyperglycemia apidrw glycosuria in patients with diabetes mellitus, probably due to diureticinduced hypokalemia. Renal impairment may reduce clearance and warrant the use of higher doses with extended dosing intervals. Torsemide is in a class of medications called diuretics water pills.
Furosemide is the most widely prescribed loop diuretic in the setting of systolic heart failure hf, yet torsemide has been shown to have less inter and intraindividual variation in. The dose can be titrated in increments of 15 mg up to a maximum of 45 mg once daily based. Torsemide is available under the following different brand names. Pdf torsemide versus furosemide in heart failure patients. Disposal dispose of your needles and disposable injection devices safely apidra package insert a sharps container. While torsemides oral bioavailability and half life theoretically render it a more efficacious drug than furosemide, the clinical outcomes of. The use of torsemide versus furosemide in patients with heart. Important member information, download a fact sheet pdf. Torsemide is contraindicated in patients with known hypersensitivity to torsemide or to sulfonylureas. Torsemide is a loop diuretic water pill that prevents your body from absorbing too much salt, allowing the salt to instead be passed in your urine. Torsemide is not approved for use by anyone younger than 18 years old.
Use of torsemide has been found to be effective for the treatment of edema associated with chronic renal failure torsemide tablets are also indicated for the treatment of high blood pressure hypertension alone or in combination with other antihypertensive agents. Administer cerenia injectable solution intravenously over 12 minutes or subcutaneously at 1 mgkg 0. Sixweek study of torsemide in patients with congestive. You may apidra package insert urgent medical attention or hospitalisation. Torsemide versus furosemide in heart failure patients. A doubleblind, randomized, multicenter study compared treatment with 10 mg torsemide, 20 mg torsemide, and 40 mg furosemide, once daily, in 70 patients with congestive heart failure who had been maintained on 40 mg furosemide daily for at least 2 weeks. It helps you make more urine and to lose salt and excess water from your body. Identification product information product name torsemide tablets 5 mg, 10 mg, 20 mg and 100 mg active substance torsemide intended uses torsemide tablet is indicated for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for norvasc amlodipine. Its molecular formula is c 16 h 20 n 4 o 3 s, its pka is 6. Torsemide demadex side effects, dosage, interactions drugs. Determination of torsemide in tablet dosage form using.
Torsemide tablets 10 mg, 90s label text avkare ndc 4229181790 torsemide tablets10 mg rx only 90 tablets each tablet contains 10 mg torsemide, usp. Torsemide oral tablet demadex is used to treat high blood pressure and edema. Moderate monitor blood glucose levels regularly in patients with diabetes, especially when pegvisomant treatment is initiated or when the dose is altered. The absorption of po administered torsemide is nearly complete in. Its chemical name is 1isopropyl34 m toluidino3pyridyl sulfonylurea and its structural formula is. May 22, 2019 torsemide tablets usp, 20 mg are available as white to offwhite, round, standard biconvex, beveled edge tablets, scored on one side and debossed with product identification 54 017 on the other side. Stable if stored in accordance with information listed on the product insert. Patients receiving torsemide were more likely to be female and had more. Find patient medical information for torsemide intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Torasemide, also known as torsemide, is a medication used to treat fluid overload due to heart failure, kidney disease, and liver disease and high blood pressure. Torsemide is a diuretic used to reduce edema swelling from multiple causes such as heart failure, renal disease, or liver disease.
Its empirical formula is c 16 h 20 n 4 o 3 s, its pka is 7. Its chemical name is 1 isopropyl34mtoluidino3pyridyl sulfonyl urea and its structural formula is. Solostar, the instructions for use included in the package leaflet must be read carefully. Pdf background diuretic treatment is the mainstay for management of congestive. Feb 06, 2007 demadex torsemide is a diuretic of the pyridinesulfonylurea class. After preliminary strength testing, compounded torsemide suspension 5 mgml for oral administration was prepared using torsemide tablets suspended in oraplus. Torsemide vials for intravenous injection contain a sterile solution of torsemide 10 mglml, polyethylene g lycal400, tromethamine, and sodium hydroxide as needed to adjust p h in water for injection. Pdf application of torsemide to two dogs with congestive. Pdf pharmacokinetic and pharmacodynamic properties of orally. Pharmacokinetic and pharmacodynamic properties of orally. Apidra insulin glulisine injection rdna origin is a recombinant. Mean plasma concentrations of torsemide over time after a single intragastric.
This article also explains that there are currently no offlabel torsemide uses. See package insert for full prescribing information. Torsemide injection is indicated for the treatment of hypertension alone or in combination with other antihypertensive agents. Mar 18, 2019 what should i avoid while taking torsemide demadex.
Shah et al metaanalysed the mortality of torasemide versus furosemide in hf patients and concluded no difference. Torsemide injection fda prescribing information, side. This medicine is used to treat high blood pressure, and edema or swelling from heart, kidney, or liver disease. Torsemide is a loop diuretic water pill that prevents your body from. Special dosage adjustment in the elderly is not necessary. No dosage adjustment is needed in patients with hepatic or renal impairment.
Clinical pharmacology studies have confirmed this site of action in humans, and effects in other segments of the nephron have not been demonstrated. Apidra solostar unitsml solution for injection in a prefilled pen. Diuretics are used to lower blood pressure or decrease swelling edema. Demadex torsemide is a diuretic of the pyridinesulfonylurea class. Torsemide versus furosemide in patients with acute heart. Torsemide tablet is indicated for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. A small randomized trial of torsemide versus furosemide in patients with renal failure found that the diuretics had similar effects on fluid and sodium excretion but torsemide led to less reninangiotensinaldosterone system activation. This emedtv page explains that torsemide is used to control high blood pressure and treat water retention in adults by reducing blood volume. Toxicological information the toxicological effects of this product have not been thoroughly studied.
High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. It is a less preferred treatment for high blood pressure. The tablets for oral administration also contain lactose monohydrate nf, microcrystalline cellulose nf, crospovidone nf, povidone usp and magnesium stearate nf. Torsemide is a white to offwhite crystalline powder. This drug is given by mouth and can be taken with food or milk. Demadex torsemide dosing, indications, interactions. The recommended starting torsemide dosage for controlling high blood pressure is 5 mg once daily. For prevention of vomiting in dogs 4 months of age and older caused by emetogenic medications or chemotherapeutic agents. When flagyl is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. After initiation of actos, and after dose increases, monitor patients carefully for signs and symptoms of heart failure e. The torsemide dosing guidelines your healthcare provider will follow will vary depending on several factors, such as how you respond to torsemide, other medical conditions you may have, and other medications you may be taking. Its empirical formula is c16h20n4o3s, its pka is 7. Drug name active ingredients strength dosage formroute marketing status te code rld rs.
A potential benefit of oral torsemide over furosemide. Baseline renal function parameters were investigated in 7 patients and were not different before treatment with either drug. Thiazolidinediones, including actos, cause or exacerbate congestive heart failure in some patients see warnings and precautions 5. Sixweek study of torsemide in patients with congestive heart failure. In addition, torsemide has a longer halflife than both furosemide and bumetanide.
It is not known whether torsemide passes into breast milk or if it could harm a nursing baby. The majority of dogs are stabilised at a dose of torasemide less than or equal to 0. Learn about side effects, warnings, dosage, and more. The tablets for oral administration also contain lactose monohydrate nf, microcrystalline cellulose nf. Should torsemide be loop diuretic of choice in systolic hf. List of drug master files dmf of torasemide active pharmaceutical ingredient api submitted to the u. See cerenia tablets package insert for complete prescribing information.
The area under the plasma drug concentration over time curve auc was 80. Torsemide demadex side effects, dosage, interactions. Torsemide injection is indicated when a rapid onset of diuresis is desired or when oral administration is impractical. Torsemide fda prescribing information, side effects and uses. Lasix is associated with very high variability in terms of absorption, so torsemide and bumetanide should be considered in patients who have a poor response, said paul mckie, md, mph, a cardiologist and internist with mayo clinic, rochester, minn. Patients receiving torsemide were more likely to be female and had more comorbidities compared with furosemidetreated patients.
A doubleblind, randomized, multicenter study compared treatment with 10 mg torsemide, 20 mg torsemide, and 40 mg furosemide, once daily, in 70 patients with congestive heart. Torsemide tablet is a loop diuretic that is fda approved for the treatment of edema associated with congestive heart failure, renal disease, or liver disease. It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. Table 1 presents the baseline characteristics of the study population based on discharge loop diuretic. Application of torsemide to two dogs with congestive heart failure article pdf available in korean journal of veterinary research 542. Torsemide definition of torsemide by the free dictionary. Tell your doctor if you are pregnant or plan to become pregnant. Side effects, dosages, treatment, interactions, warnings. The actions of torsemide can be mediated by several mechanisms operating. Torsemide is used alone or in combination with other medications to treat high blood pressure. Demadex can be used alone or in combination with other antihypertensive agents. Torasemide api dmfs us drug master file dmf details. Capitals indicate lifethreatening, underlines indicate most frequent. Demadex torsemide dose, indications, adverse effects.
Diuretics furosemide lasix, bumetanide bumex, torsemide demadex, chlorothiazide diuril, hydrochlorothiazide hctz use. Sixweek study of torsemide in patients with congestive heart. Torsemide tablets usp, 20 mg are available as white to offwhite, round, standard biconvex, beveled edge tablets, scored on one side and debossed with product identification 54 017 on the other side. Torsemide is also indicated for the treatment of hypertension. The slope and intercept of the equation of the regression line are 0. Torsemide use began to increase in 2006 and rose to approximately 30% of loop diuretic use in 2010. Torsemide is an effective diuretic for many patients with renal impairment. Its chemical 8 name is 1isopropyl34mtoluidino3pyridyl sulfonyl urea and its structural formula 9 is. Advantages of the new loop diuretic torasemide over furosemide in. Dec 23, 2019 torsemide is a white to offwhite c rys ta lline powder. What should i avoid while taking torsemide demadex. Find patient medical information for torsemide oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
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