Aliskiren alleviates doxorubicininduced nephrotoxicity by. A novel hybrid cytokine il233 mediates regeneration. Effect of coenzymeq10 on doxorubicininduced nephrotoxicity in rats. The interplay between genetic background and sexual. Animals were divided into normal group and doxorubicin treated group injecting doxorubicin as a dose of 2. Alleviation of doxorubicin induced nephrotoxicity by clerodendrum volubile leaf extract in wistar rats. Research article possible protective effect of diacerein on doxorubicininduced nephrotoxicity in rats marwam. The anthracycline antitumor drug doxorubicine causes severe nephrotoxicity in a variety of experimental animals and may be nephrotoxic to humans. Possible protective effect of diacerein on doxorubicininduced nephrotoxicity in rats. Heart and kidney tissues were harvested after euthanasia for histological and. At the end of the 10th day, kidney tissues were removed for light. Pdf protective effect of solanum torvum on doxorubicin. Hypoalbuminemia and hypercholesterolemia appeared after the doxorubicin injection. This leads frequently to acute kidney injury, and current problems are discussed.
A novel hybrid cytokine il233 mediates regeneration following. In both strains, female sex was protective against dox induced nephrotoxicity. Nephrotoxicity is one of the complications the use of doxorubicin dxr which may be caused by the formation of free radicals. Trpc3nox2 complex mediates doxorubicininduced myocardial. In this study, 24 adult male wistar albino rats were used. The ameliorative effect of ellagic acid and rosemarinic. We conclude that captopril, olmesartan, melatonin and c21 exerted a.
Doxorubicininduced in vivo nephrotoxicity involves. Pdf druginduced nephrotoxicity is one of the most common causes of acute kidney injury. Doxorubicininduced changes in the renal tissue of rats include increased glomerular capillary permeability and tubular atrophy saad et al. Drug induced nephrotoxicity remains a major problem in the clinical setting, where the use of nephrotoxic drugs is often unavoidable. Doxorubicininduced oxidative injury of cardiomyocytes do we. Thyme oil and thymol abrogate doxorubicin induced nephrotoxicity and cardiotoxicity 43 homogenized in isotonic saline 0. Yiqi fumai lyophilized injection attenuates doxorubicininduced cardiotoxicity, hepatotoxicity and nephrotoxicity in rats by inhibition of oxidative stress, inflammation and apoptosis yue gu, a aichun ju, b bingjie jiang, a jingze zhang, c shuli man, d changxiao liu e and wenyuan gao a. The aim of this study was to investigate the effects of pravastatin ps on doxorubicin induced nephrotoxocity. Pdf effects of quercetin on kidney injury induced by doxorubicin.
Nad, an antioxidant agent, against nephrotoxicity induced by doxorubicin dxr. Dox is one of the key chemotherapeutic drugs for cancer treatment, but its. Elucidating the timedependent changes in the urinary. The anthracycline antitumor drug doxorubicine causes severe nephrotoxicity in a variety of experimental animals and may be. Protective effect of solanum torvum on doxorubicin induced nephrotoxicity in rats. Research article possible protective effect of diacerein. Phytomodulatory potential of lycopene from lycopersicum. Plants free fulltext naringenin regulates doxorubicininduced. Protection from doxorubicininduced nephrotoxicity by. Research article dalbergioidin ameliorates doxorubicin. Doxorubicin dox is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Rats intraperitoneally injected with dox at a dose of 2 mgkg b.
Abdelrahman 1 department of pharmacology, faculty of medicine, elminia university, elminia, egypt. Doxorubicin dxr, an anthracycline antibiotic and is used for the treatment of a variety of neoplastic conditions including leukemias, lymphomas and solid tumors. Alleviation of doxorubicininduced nephrotoxicity by. This study investigated whether dox has the ability to cause nephrotoxicity in vivo and if so, whether it is linked.
Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Effects of vitamin d on kidney histology and trpv1. Female rodents have been shown to be protected against several features of dox induced nephrotoxicity. The rats were divided into control, nad alone, doxorubicin 20 mgkg, i.
About europe pmc funders joining europe pmc governance roadmap outreach tools. The kidney is a major target for drug induced toxicity. Here, using doxorubicininduced nephrotoxic renal injury model, we. International journal of molecular sciences article the ef. This study investigated whether dox has the ability to cause nephrotoxicity in vivo and if so, whether it is linked to oxidative stress os. Doxorubicininduced nephropathy rats were held in a restrainer and received 5 mgkg in two injections at an interval of 7 days. This preliminary study was designed to investigate the ameliorative effects of methanolic leaf extract of clerodendrum volubile mecv against dox induced nephrotoxicity in rats. Doxorubicin, nephrotoxicity, pentoxifylline, rabbits introduction oxorubicin dox is an anthracycline antineoplastic drug1.
Milk thistle herbal preparations are produced from the seeds of silybum marianum l. The resultant homogenates were then centrifuged at 3000 rpm for 15 min, and the supernatants were aspirated and frozen at 30oc, until. Doxorubicin dox, a wellknown chemotherapeutic drug, has been reported to induce numerous toxic side effects including renal toxicity. Protective effects of madecassoside against doxorubicin. Dia 25 and 50 mgkgday was administered orally to rats for 15 days, in the presence or absence of nephrotoxicity induced by a single. Original article effects of vitamin d on kidney histology. This however, the optimal clinical use of dxr has been cur. Pdf effect of meloxicam cyclooygenase2 inhibitor versus. Pdf on jan 1, 2020, dalia mahmoud abdelmonem elsherbini and. Doxorubicin dox, a prominent anticancer agent has enjoyed considerable popularity in the last few decades because of its usefulness in the management of various forms of cancers, but its organotoxic potential cardio, hepatoand nephrotoxicity has constrained on its clinical use.
Possible protective effect of diacerein on doxorubicin. Doxorubicin dox is a potent anticancer agent with cytotoxic effects which limit its clinical usage. Comparison of nephrotoxicity of pirarubicin and doxorubicin. Pemetrexed induced acute kidney injury in patients with nonsmall cell lung cancer. Thyme oil was subjected to gcms analysis, which indicated that thymol was the major constituent representing 33. Il233, a novel il2 and il33 hybrid cytokine, ameliorates. Protective effect of solanum torvum on doxorubicininduced. Doxorubicin is a highly effective anticancer agent but also induces myocardial atrophy through a largely unknown mechanism. Possible protective effect of diacerein on doxorubicininduced. There was a strong correlation between dox induced renal pathology and dox induced cardiac dysfunction. Modulating effect of carvedilol on doxorubicininduced. The aim of this study was to investigate the effects of nicotinamide nad, an antioxidant agent, against nephrotoxicity induced by doxorubicin dxr.
Protective effect of carvedilol alone and coadministered. Doxorubicin doxinduced nephropathy hampered its antineoplastic efficiency. Yiqi fumai lyophilized injection attenuates doxorubicininduced cardiotoxicity, hepatotoxicity and nephrotoxicity in rats by inhibition of oxidative stress, in. The precise mechanism of the dxrinduced nephrotoxicity din has not yet been determined. We investigated changes in kidney tissue following doxorubicin treatment and the effects of vitamin d on kidney tissue and trpv1 channels. Introduction doxorubicin dxr is an anthracycline glycoside antibiotic that has broadspectrum antitumor activity against a variety of human solid tumors such as ovarian, breast, and lung cancers as well as several other cancers and hematologic malignancies. All four substances significantly diminished the level of oxidative burden and prevented the reduction of glomerular density and modestly prevented the increase of glomerular size. Druginduced nephrotoxicity is a major cause of acute kidney injury 1. The rats were divided into control, doxorubicin 15 mgkg, i. Yiqi fumai lyophilized injection attenuates doxorubicin. Recent studies have indicated a reparative function for tregs and ilc2. This study highlights the importance of studying the interaction between sex and genetic background to determine the risk of dox induced cardiotoxicity. Nephrotoxicity is one of the important side effects of anthracycline antibiotics. Pdf druginduced nephrotoxicity and medicinal plants.
Although the exact mechanism of doxinduced nephrotoxicity remains unknown, it is believed to be mediated through free radical formation, irondependent oxidative damage of biological macromolecules and membrane lipid peroxidation pritsos. Dual effects of quercetin in doxorubicininduced nephrotoxicity in. Clinical presentation and risk factors of doxorubicininduced cardiotoxicity. Effects of quercetin on kidney injury induced by doxorubicin. Quercetin attenuating doxorubicin induced hepatic, cardiac and renal toxicity in male albino wistar rats sudhanshu jambhulkar, swathi deshireddy, dinesh babu jestadi and latha periyasamy department of biochemistry and molecular biology, school of life sciences, pondicherry university, puducherry 605014, india abstract doxorubicin dox is. Nephrotoxicity is one of the limiting factors for using doxorubicin dox. Pemetrexed induced acute kidney failure following irreversible renal damage. Interleukin 1 has major role in dox induced nephrotoxicity, so we investigated the effect of interleukin 1 receptor antagonist diacerein dia on dox induced nephrotoxicity.
Administration of dox is a source of adverse effects like genotoxicity, nephrotoxicity, hepatotoxicity, and cardiotoxicity, which restricts its clinical use 16. Sexual dimorphism of acute doxorubicininduced nephrotoxicity in. However, according to many researchs, dxrinduced cellular damage occurs due to plasma membrane injury caused by free anthracycline radicals. Protective effect of captopril, olmesartan, melatonin and. Dual effects of quercetin in doxorubicininduced nephrotoxicity in rats and its modulation of the cytotoxic activity of. The aim of present study was to determine the protective effects of quercetin against doxorubicin induced kidney injury with light microscopy. Therefore, male sprague dawley rats were divided into eight groups, control group, ellagic acid 10mgkg, p. This study aimed to assess the preventive effects of thyme oil and thymol on doxorubicin dox induced renotoxicity, cardiotoxicity, and oxidative stress in wistar rats. Here, we demonstrate that inhibiting transient receptor potential canonical 3 trpc3 channels abolishes doxorubicin induced myocardial atrophy in mice. Doxorubicin dxr is an antineoplastic agent of the anthracycline group, and may show nephrotoxic effects in animal models and humans.
Toxicity and safety evaluation of doxorubicinloaded cockleshell. Systemic toxicity associated with doxorubicin administration in cats deborah a. This study investigated the effects of different doses of qur on doxorubicin dox. One strategy to avoid such problems would be the development of drugs with decreased nephrotoxic potential. Krawiec, dvm, phd the systemic toxicity of doxorubicin, 30 mgm2 body. Gaertn preliminary evidence suggests milk thistle may reduce side effects such as hepatotoxicity, nephrotoxicity, radiation induced mucositis and dermatitis, doxorubicin induced. Quercetin attenuating doxorubicin induced hepatic, cardiac.
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